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NanOX system tested during experimental kidney autotransplantation procedure

This was probably one of the most complex and technologically advanced procedures currently being performed in our country in preclinical and clinical research,” is how Prof. Kovacs says of the kidney autotransplant surgery. Ph. n. med. Maciej Kosieradzki of Warsaw Medical University. The team led by him transplanted the organ, which was left uncirculated for about 30 minutes and then stored for 12 hours at a temperature only slightly below normal body temperature. Without using blood. NanOX is a comprehensive and proprietary system of devices and innovative fluids for extracorporeal storage, as well as organ regeneration for transplantation. It consists of NanOX 4K perfusion fluid, the NanOX Recovery Box universal perfusion device, which monitors vital organ functions, and a proprietary perfusion protocol. The usefulness of the solution has been confirmed by a series of experiments, the last of which, in 2023, resulted in successful perfusion of a kidney, which lasted about 6 days. They prepared the research team, led by Prof. Maciej Kosieradzki, MD, of Warsaw Medical University, president of the Polish Transplantation Society, for the most important test, the autotransplantation operation, which took place in July 2024. – We were the first to successfully perform a kidney autotransplantation procedure using synthetic hemoglobin-depleted preservative fluid under subnormal conditions. In practice, this was a successful preclinical trial, but the patient could not yet be human, so we performed it in a domestic pig – This is what Prof. Kosieradzki says about the experiment. Kosieradzki, who combines his work on the project with his duties as head of the General and Transplant Clinic at the Infant Jesus Clinical Hospital.

Course of the experiment

The experiment consisted of taking one kidney from an animal after a 30-minute cardiac arrest, perfusing it with NanOX fluid and using the NanOX Recovery Box device under extracorporeal conditions in subnormothermia, i.e. at 25 degrees Celsius, for 12 hours. This technology, combined with the unique NanOX 4K fluid, which uses nanoparticles to deliver oxygen to the organ and take away carbon dioxide, makes it possible to provide the organ with the necessary substrates for metabolism, oxygenation and nutrition. In practice, this means that the kidney has not only retained its suitability for transplantation throughout this time, but also regeneration processes have been taking place in it. In the next step, after the researchers removed the second kidney, they implanted the animal with the organ, which had previously undergone extracorporeal perfusion. Then, for the next two weeks, intensive observation was carried out, monitoring the health of the “patient” and the function of the transplanted kidney. – Already on the eighth day after the procedure, the animal became fully functional, as did the transplanted kidney, which was confirmed by the results of biochemical tests,” recalled Dr. n. biol. Eng. Jaroslaw Wolinski of the Polish Academy of Sciences.

Further prospects

Successful autotransplantation is an important step toward commercialization of the NanOX system, according to Piotr Mierzejewski. – The results of our experiment open up new possibilities in the field of transplantation. We have proven that our system not only allows organs to be stored much longer, but also makes it possible to regenerate them and, who knows, in the future, to treat them as well – evaluates the vice president of NanoGroup S.A. Read more about our project and autotransplantation: TVP3 Warsaw (24.07.2024), TVP1 Teleexpress, Warsaw University of Technology, MAMBIZNES.PL, BUSINESS PULSE, COWZDROWIU.PL, BANKIER.PL, RYNEKZDROWIA.PL, CEO.COM.PL, HEJTO.PL, MEDICALPRESS.PL, GOSPODARKA.SOS.PL, PULS MEDYCYNY, ISB HEALTH, PAP BUSINESS, BIOTECHNOLOGIA.PL, MZDROWIE.PL, STREFA INWESTORÓW, LABNEWS, INFOSTREFA, GPW.

Prof. Tomasz Ciach

Founder, Member of the Management Board of NANOGROUP S.A.

Nanotechnology expert. Professor at the Faculty of Chemical and Processing Engineering, Warsaw University of Technology, head of the Biotechnology and Bioprocessing Division. Author of two technologies that are already in production stage, 12 granted patents and over 50 publications. Founder of BioMedLab research group, consultant in numerous companies (AstraZeneca, Procter and Gamble, Reckit, Adamed, Balton, Galmed). Work on various aspects of Biomedical Engineering, mostly on biomedical nanotechnology, active coatings for medical implants, nanoparticles for cancer treatment, biodegradable and nonbiodegradable implants, bone and vascular prosthesis. He gives rare, but already brilliant example of how brave ideas become socially and financially valuable.

Piotr Mierzejewski

Vice President of the Management Board of NANOGROUP S.A.

Clinical pharmacology specialist, former advisor to the Minister of Health on drug policy. He negotiated Poland’s accession to the EU in the field of pharmacy, responsible for the implementation of EU directives in the field of pharmacy into the Polish legal system. Co-founder of the Office for Registration of Medicinal Products, Medical Devices and Biocidal Products. Owner of a consulting company cooperating with international pharmaceutical companies in the field of introducing new technologies to the Polish market.

Przemysław Mazurek

President of the Management Board of NANOGROUP S.A.

Associated with the health market since 2004. As Managing Director, he restructured and developed the most dynamically operating Medical Center in the Podkarpacie region, creating and setting new standards of customer service quality on the market. Co-creator of the first solution in Poland for online registration of medical appointments. Co-founder of the first and only Infertility Treatment Clinic (MEDICOR) in Podkarpacie, which he headed as the President until 2009. He was responsible for the development of health insurance in the PZU Group. As Vice President of PZU Pomoc S.A. created the largest medical TPA in Poland to handle health insurance. Co-founder of the first drug insurance in Poland. Since 2015, he has been active in the field of Wealth Management and advises on management and finance. A graduate of International Economic and Political Relations as well as Management and Marketing at the Warsaw School of Economics.

Przemysław Mazurek

President of the Management Board of NANOGROUP S.A.

Associated with the health market since 2004. As Managing Director, he restructured and developed the most dynamically operating Medical Center in the Podkarpacie region, creating and setting new standards of customer service quality on the market. Co-creator of the first solution in Poland for online registration of medical appointments. Co-founder of the first and only Infertility Treatment Clinic (MEDICOR) in Podkarpacie, which he headed as the President until 2009. He was responsible for the development of health insurance in the PZU Group. As Vice President of PZU Pomoc S.A. created the largest medical TPA in Poland to handle health insurance. Co-founder of the first drug insurance in Poland. Since 2015, he has been active in the field of Wealth Management and advises on management and finance. A graduate of International Economic and Political Relations as well as Management and Marketing at the Warsaw School of Economics.