On October 1, 2024, NanoGroup S.A. filed a patent application with the Polish Patent Office for an innovative device for organ perfusion, NanOX Recovery Box. This modern device is the only one on the market that enables comprehensive storage of organs for transplantation (kidneys, liver, heart) outside the body, regardless of temperature, perfusion mode, and type of perfusion fluid. Obtaining a patent is a key step in the certification process, and in the long term – commercialization of the device.
The NanOX Recovery Box device is part of a larger project, the NanOX system, on which researchers from NanoGroup, Warsaw University of Technology and the A4BEE technology company worked. Previous tests and the autotransplantation procedure have confirmed the effectiveness and innovation of this solution. Compared to the technologies currently on the market, the NanOX Recovery Box provides significant advantages in terms of organ storage and their later use for transplantation.
Versatility as a key asset
The NanOX Recovery Box has been designed to work effectively and efficiently both as part of the NanOX system and as a standalone device. What sets it apart from other solutions is its versatility – the device allows for safe storage and transport of not only kidneys, but also liver and heart.
Moreover, the device is compatible with various types of perfusion fluids available on the market and allows flexible settings of perfusion mode and temperature, from normothermic, subnormothermic, to hypothermic and mixed conditions. The key condition for the success of the process is the use of an adequately oxygenated fluid and maintaining appropriate physiological parameters, such as arterial and venous pressure or temperature.
The device also features advanced monitoring of vital organ functions, which increases storage efficiency.
From testing to patent application
During the work on the NanOX Recovery Box, three prototypes of the device were created. The first two were developed by NanoGroup researchers in cooperation with the Warsaw University of Technology, while the third, most professional model, was created with the participation of A4BEE. The latest prototype, created in September 2024, underwent operational tests in conditions close to real ones.
The effectiveness of earlier prototypes was confirmed by a series of experiments, the most important of which was a successful autotransplantation of a pig kidney, carried out in July 2024. From March 2020 to September 2023, a number of studies were also conducted on isolated organs, which confirmed the key functions of the device.
All tests were carried out in cooperation with the Jan Kielanowski Institute of Animal Physiology and Nutrition of the Polish Academy of Sciences and the team led by prof. dr hab. med. Maciej Kosieradzki from the Clinic of General and Transplant Surgery of the University Clinical Center of the Medical University of Warsaw.
NanOX Recovery Box: a revolution in transplantology
NanOX Recovery Box, thanks to its versatility and advanced technology, responds to one of the most important unmet needs in transplantology – increasing the number of organs available for transplantation and improving the health safety of patients.
The device enables organ regeneration during perfusion and, in the future, perhaps also treatment in extracorporeal conditions.
Obtaining a patent is one of the key steps towards certification and commercialization of this breakthrough solution.
