NEWS
< back to news list

Successful liver perfusion another step in the development of NanoSanguis SA’s innovative perfusion system

The conducted pig liver perfusion is another step taken by the company to introduce an innovative organ perfusion system to the Polish market. NanoGroup’s first pig liver perfusion using the “NanOX Recovery Box” organ perfusion device and NanOx 10 fluid was successfully completed. The research conducted so far has only included perfusion of porcine kidneys, but NanoGroup’s goal is to expand the utility of the device and NanOx fluid to other organs. The liver was taken in the DBD model, in which the warm ischemia period is eliminated, the cold ischemia time of the organ was 8.5 hours, and the total perfusion time was 4.5 hours. According to the developed protocol, the liver was perfused under hypothermic conditions for the first hour after being connected to the device, then, the fluid temperature was raised from 10°C to 37°C for another hour in a controlled manner, and once normothermic conditions were reached, the organ was perfused for 2.5 hours. Throughout the study, liver enzyme activity remained normal, and fluid flow in the hepatic artery and portal vein increased as predicted by the research team. The liver analysis included eg. histopathological evaluation of the organ biopsies, performed by Dr. Agata Cyran of the Department of Pathomorphology at the Medical University of Warsaw, which showed the absence of increased damage in the vast majority of biopsies. The study was carried out in cooperation with the Tchaikovsky Institute of Animal Physiology and Nutrition. Jan Kielanowski of the Polish Academy of Sciences and a team led by the prof. Dr. hab. med. Maciej Kosieradzki and Dr. hab. n. med. Piotr Domagała Department of General and Transplant Surgery at the University Clinical Center of Warsaw Medical University.

Copyright © NanoGroup 2023

Prof. Tomasz Ciach

Founder, Member of the Management Board of NANOGROUP S.A.

Nanotechnology expert. Professor at the Faculty of Chemical and Processing Engineering, Warsaw University of Technology, head of the Biotechnology and Bioprocessing Division. Author of two technologies that are already in production stage, 12 granted patents and over 50 publications. Founder of BioMedLab research group, consultant in numerous companies (AstraZeneca, Procter and Gamble, Reckit, Adamed, Balton, Galmed). Work on various aspects of Biomedical Engineering, mostly on biomedical nanotechnology, active coatings for medical implants, nanoparticles for cancer treatment, biodegradable and nonbiodegradable implants, bone and vascular prosthesis. He gives rare, but already brilliant example of how brave ideas become socially and financially valuable.

Piotr Mierzejewski

Vice President of the Management Board of NANOGROUP S.A.

Clinical pharmacology specialist, former advisor to the Minister of Health on drug policy. He negotiated Poland’s accession to the EU in the field of pharmacy, responsible for the implementation of EU directives in the field of pharmacy into the Polish legal system. Co-founder of the Office for Registration of Medicinal Products, Medical Devices and Biocidal Products. Owner of a consulting company cooperating with international pharmaceutical companies in the field of introducing new technologies to the Polish market.

Przemysław Mazurek

President of the Management Board of NANOGROUP S.A.

Associated with the health market since 2004. As Managing Director, he restructured and developed the most dynamically operating Medical Center in the Podkarpacie region, creating and setting new standards of customer service quality on the market. Co-creator of the first solution in Poland for online registration of medical appointments. Co-founder of the first and only Infertility Treatment Clinic (MEDICOR) in Podkarpacie, which he headed as the President until 2009. He was responsible for the development of health insurance in the PZU Group. As Vice President of PZU Pomoc S.A. created the largest medical TPA in Poland to handle health insurance. Co-founder of the first drug insurance in Poland. Since 2015, he has been active in the field of Wealth Management and advises on management and finance. A graduate of International Economic and Political Relations as well as Management and Marketing at the Warsaw School of Economics.

Przemysław Mazurek

President of the Management Board of NANOGROUP S.A.

Associated with the health market since 2004. As Managing Director, he restructured and developed the most dynamically operating Medical Center in the Podkarpacie region, creating and setting new standards of customer service quality on the market. Co-creator of the first solution in Poland for online registration of medical appointments. Co-founder of the first and only Infertility Treatment Clinic (MEDICOR) in Podkarpacie, which he headed as the President until 2009. He was responsible for the development of health insurance in the PZU Group. As Vice President of PZU Pomoc S.A. created the largest medical TPA in Poland to handle health insurance. Co-founder of the first drug insurance in Poland. Since 2015, he has been active in the field of Wealth Management and advises on management and finance. A graduate of International Economic and Political Relations as well as Management and Marketing at the Warsaw School of Economics.